This new study describes a novel methodology that enables delivering prime-boost vaccination with a single injection.

In collaboration with the Institute of Biomedical Engineering, we have developed a microfluidics-based method to encapsulate the booster vaccine into microcapsules for programmable delayed delivery within the body. In preclinical trials, the single-dose approach provided strong protection against malaria, matching the efficacy of the standard multi-dose vaccination regimen.

 If successfully translated to the clinic, this exciting new technology could offer a simpler, more effective approach to immunisation, particularly in regions where access to follow-up healthcare is limited, eliminating the need for booster shots and increasing immunisation coverage in hard-to-reach communities.

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Read more in the Institutional press releases:

Press release @ University of Oxford Website

Press release @ Nuffield Department of Medicine Website